CYSTIC FIBROSIS AUTOANTIBODY SIGNATURES ASSOCIATE WITH STAPHYLOCOCCUS AUREUS LUNG INFECTION OR CYSTIC FIBROSIS-RELATED DIABETES

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes

IntroductionWhile cystic fibrosis (CF) lung disease is characterized by persistent inflammation and infections and chronic inflammatory diseases are often accompanied by autoimmunity, autoimmune reactivity in CF has not been studied in depth.MethodsIn this work we undertook an unbiased PH PAPER approach to explore the systemic autoantibody repertoi

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Human leukocyte antigen evolutionary divergence as a novel risk factor for donor selection in acute lymphoblastic leukemia patients undergoing haploidentical hematopoietic stem cell transplantation

IntroductionThe human leukocyte antigen (HLA) evolutionary divergence (HED) reflects immunopeptidome diversity and has been shown to predict the response of tumors to immunotherapy.Its impact on allogeneic hematopoietic stem cell transplantation (HSCT) is controversial in different studies.MethodsIn this study, we retrospectively analyzed the clini

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